Disruption of Adipose Tissue Metabolism by Glucocorticoids Is Attenuated With LXRβ Antagonism
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چکیده
منابع مشابه
Effects of Glucocorticoids on Metabolism of Adipose Tissue in Vitro*
The adrenal cortex is necessary for development of fatty liver (2, 3) and increased plasma free fatty acids in numerous situations (4-6). It has been difficult, however, to demonstrate direct effects of glucocorticoids on fat metabolism. The role of the adrenal cortex in fat metabolism is generally considered to be a permissive one. Pancreatectomized rats deprived of either the pituitary or adr...
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Obesity is recognized as an epidemic health problem worldwide. In humans, the accumulation of omental rather than subcutaneous fat appears to be tightly linked to insulin resistance, type 2 diabetes and cardiovascular disease. Differences in gene expression profiles in the adipose tissue comparing non-obese and obese subjects have been well documented. However, to date, no comparative proteomic...
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Slices from adipose tissue and liver were incubated with uniformly labeled C14-isoleucine and the respiratory carbon dioxide, fatty acids, and nonsaponifiable lipids were isolated and analyzed for radioactivity. Organic acids were qualitatively identified by chromatography and autoradiography. Adipose tissue oxidized isoleucine to carbon dioxide a t a rate greater than that of liver. Conversion...
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Adipose tissue in man is a major site for cholesterol storage. In obesity over half of total body cholesterol may reside within this tissue; however, relatively little attention has been directed toward understanding the cholesterol metabolism and its relationship to whole body cholesterol homeostasis in this tissue. In this review the factors which influence cholesterol storage are discussed, ...
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Rat epididymal fat pad segments were incubated with glucose labeled uniformly with W, and with tritium in position 2, and in positions 1,3, and 6. Under conditions of high lipogenesis, 70 to 80% of tritium (T) from position 2 was recovered in water, with the remainder in lipid glycerol, fatty acids, and lactate. The highest tritium retention, relative to carbon, was in glycerol, with T:W ratios...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2021
ISSN: 2472-1972
DOI: 10.1210/jendso/bvab048.1674